|
KMID : 0358420110540010026
|
|
Korean Journal of Obstetrics and Gynecology
2011 Volume.54 No. 1 p.26 ~ p.36
|
|
|
MATERNAL SERUM LEVELS OF C-REACTIVE PROTEIN AND PLACENTAL LEVELS OF IL-6, LIPID PEROXIDE, AND PROTEIN CARBONYL IN PRETERM BIRTH ACCORDING TO HISTOLOGIC CHORIOAMNIONIT
|
|
Yoon Dae-Seok
Kim Yoon-Ha
Kim Chul-Hong
Cho Moon-Kyoung
Kim Jong-Woon
Cho Hye-Yon
Kim Seok-Mo
Kang Woo-Dae
Lee Ki-Ho
Song Tae-Bok
|
|
|
Abstract
|
|
|
Objective: To evaluate predictive value of maternal serum white blood cells (WBCs), C-reactive protein (CRP) levels, placental interleukin-6 (IL-6), lipid peroxide, and protein carbonyl levels in preterm birth according to histologic chorioamnionitis (HCA).
Methods: This cohort study included 45 cases of preterm delivery with preterm labor and intact membranes (preterm labor [PTL] group; n=16) and preterm premature rupture of membranes (preterm premature rupture of membranes [PPROM] group; n=29). Blood samples at admission and placental sample at postpartum were collected. HCA was diagnosed in the presence of neutrophils infiltration into the subamnionic space.
Results: The incidence of HCA was significantly higher in PPROM group than PTL group. Maternal serum WBC and CRP levels at admission, and placental IL-6, lipid peroxide, and protein carbonyl levels in HCA group were significantly higher than group without HCA. Maternal serum CRP levels at admission, and placental IL-6, lipid peroxide, and protein carbonyl levels of PPROM group with HCA were significantly higher than PPROM group without HCA. Maternal serum CRP levels at admission of 7 days and more latency period (n=14) were significantly lowered than those of less than 7 days latency period (n=15). The cut-off points of CRP determined with the receiver operating characteristic curves was 0.875 mg/dL. Perinatal morbidity such as respiratory distress syndrome, intraventricular hemorrhage, pneumonia in HCA group was significantly higher than group without HCA.
Conslusion: Maternal serum CRP on admission may be possible a predictor for duration of the latency period in PPROM.
|
|
|
KEYWORD
|
|
|
Preterm birth, Histologic chorioamnionitis, C-reactive protein, Lipid peroxides, Protein carbonyls
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
  
|
|